For environmental, social and governance (ESG) norms to integrate satisfactorily into Asia’s business and society, it is imperative for policy, principle and profit to come together. The region trails both Europe and the US in developing a holistic ESG framework and in curbing harmful climate, governance and social practices. This poses a knotty problem for investors and businesses, because Asia is a core component of the global supply chain, a burgeoning consumer market and a growing source of wealth. What needs to happen to create realistic sustainability targets that take into account the region’s various risks, along with its opportunities?